Efficacy evaluation of pepsin enzyme-based gel in chemo-mechanical caries removal on primary anterior teeth: a randomized controlled clinical study

Objective: To evaluate the efficacy of a new pepsin enzyme-based gel compared with Carisolv as CMCRagent. Clinical and radiographical evaluations recurrent caries were made 3 6 months after treatment.Material Methods: A split-mouth designed randomized controlled clinical study was carried out on 40 primaryanterior teeth children aged between 4-7 years. Pepsin solution appliedto carious lesions until complete removal caries. The both agents evaluated by number ofapplication times to remove all Recurrent clinically radiographically 6months treatment. Results: Results showed no statistically significant differences in removalby application (P = 0.919). Concerning caries, evaluationafter three six two groups 0.574, P =0.547, respectively). Conclusion: can be considered similar regarding itsefficacy CMCR agent for small primary anterior years old. KEYWORDSCarisolv; Chemo-mechanical removal; enzyme; Caries; Minimally invasive dentistry.